Prior retrospective studies analyzed the prognostic and predictive role of biomarkers related to the mTOR pathway, assessed only on the primary renal cancer, underlining the poor prognostic role of 4EBP1 expression, which seemed to be related to high-grade and stage of tumors and to worse RFS, as well as S6RP expression [14, 15]. The gene discussed is MTOR; the disease is renal carcinoma.