Consistent with this, aspirin was shown to upregulate glutaminolysis-associated genes such as GLS 1, alanine-serine-cystine transporter 2 (ASCT2), large neutral amino acid transporter 1 (LAT1), and glutamic-pyruvic transaminase 2 (GPT2) in PIK3CA mutant CRC cells [58]. This evidence concerns the gene PIK3CA and colorectal carcinoma.