MTOR and colorectal carcinoma: In 5 mmol/L aspirin-treated CRC cells, aspirin has been shown to reduce mTOR signalling by inhibiting phosphorylation and therefore activation of the downstream effectors ribosomal protein S6 kinase-1 (S6K1) and eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) which are important for protein synthesis [100].