Following the studies in hematologic malignancies, many studies have found amplifications of Bcl-2 family genes, such as MCL1 and BCL2L1 (responsible for encoding Bcl-xL) in solid tumors, such as lung, breast, uterine and bladder cancer, which was confirmed by The Cancer Genome Atlas data [3]. The gene discussed is BCL2L1; the disease is urinary bladder cancer.