Co-therapy may also be a possible solution, using the BH3 mimetic ABT-737, capable of Bcl-2 and Bcl-xL inhibition, rendering the chondrosarcoma sensitive to chemotherapy (doxorubicin or cisplatin) regimens, according to the findings of van Oosterwijk et al. [102], in which they described the high expression of Bcl-2 and Bcl-xL in the mesenchymal, clear cell, and dedifferentiated chondrosarcoma subtypes. The gene discussed is BCL2L1; the disease is chondrosarcoma.