Papaverine was demonstrated to inhibit human prostate cancer cell (PC-3) growth by inducing mitochondrial-mediated apoptosis, cell cycle arrest, and downregulation of the NF-κB/PI3K/Akt signaling pathway [44], and vasodilating effect to increase delivery of NDV to the tumor site. This evidence concerns the gene NFKB1 and Familial prostate cancer.