Combining troponin blood levels with two echo-derived strain parameters has yielded a diagnostic score with a sensitivity of 94 % and specificity of 97 % for diagnosing cardiac involvement in AL amyloidosis patients (Nicol et al., 2020[97]) NT-proBNP serves as an independent predictor of death and the need for dialysis, with levels exceeding 8500 ng/L associated with hazard ratios of 3.3 for death and 3.0 for dialysis. The gene discussed is NPPB; the disease is AL amyloidosis.