The increase levels of GPR183 ligand 7α,25-HC produced by CH25H and CYP7B1 can exacerbate the inflammatory response through the GPR183-dependent activation of ILC migration, the recruitment of myeloid cells, and tissue remodeling, and knocking out of GPR183 was able to alleviate the severity of CD40-Ab-induced colitis. This evidence concerns the gene GPR183 and colitis.