TNF and colitis: The activation of LXRs in a mouse colitis model can suppress the expression of inflammatory factors such as IL-1β, IL-6, IL-17A, TNFα, and chemokines such as CXCL1/KC, CXCL2/MIP2, CXCL8/IL-8, CCL2/MCP1 and CXCL10 in the colon tissue (17).