Therefore, SIRT1 imbalances in the immune system can result in the development and progression of IBD, and it is speculated that SIRT1 decreases the production of inflammatory cytokines by macrophage and Th1/Th17 cells through the activation of CH25H, and enhance the LXR/ABCA1 pathway to exert anti-inflammatory effects. This evidence concerns the gene SIRT1 and inflammatory bowel disease.