TNF and colitis: (17) observed that LXR-deficient mice are more susceptible to suffer dextran sodium sulfate (DSS)- and 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis and showed a slower recovery and decreased survival, while LXRs agonists can inhibit the expression of inflammatory cytokines, i.e. TNFα, and the recruitment of CD11b+ immune cell populations, and reduce the infiltration of pro-inflammatory Th17 cells in the colon epithelium.