,64 Pharmacological inhibition of DOT1L with small molecules selectively kills MLL-r leukemia cells in vitro and in vivo.65,66 In line with this, we found that a subset of MLL-AF4-expressing lymph glands from larvae raised on SGC0946-containing food were even smaller than WT lymph glands, indicating that MLL-AF4-expressing hemocytes are particularly sensitive to pharmacological gpp/DOT1L inhibition. Here, KMT2A is linked to leukemia.