ChIP-seq analysis reveals significant overlap between PML-, ER-, and Myc-bound promoters, suggesting their coordinated regulation of target gene expression, including genes involved in breast cancer stem cells (BCSCs), such as <i>JAG1</i>, <i>KLF4</i>, <i>YAP1</i>, <i>SNAI1</i>, and <i>MYC</i>. Here, ESR1 is linked to breast cancer.