APOE and atherosclerosis: Because TMA lyase inhibition using first (DMB) and second-generation (FMC) small molecule inhibitors (Fig. 1a) was effective in ameliorating the inflammatory disease processes underlying the ApoE−/− mouse model of atherosclerosis [26, 27], we questioned if TMA lyase inhibition using these same inhibitors would also be beneficial in another inflammatory disease model, CIA.