Additionally, we have found a significant association between the expression of these ligands in breast tumor cells and the expression of their respective receptors, IL-6R, CXCR-4, and CCR-2, in spindle-shaped stromal cells, not associated to the vasculature, found within the tumor microenvironment of these BCPs (Labovsky et al., 2015). This evidence concerns the gene CXCR4 and neoplasm.