Liu et al. (Liu et al., 2019) investigated the effects of Wenyu-jin extracts on A498 and Sw-156 cells (renal cell carcinoma) and analyzed its mechanism of action; analysis showed that Wenyu-jin extracts caused mitochondrial dysfunction in A498 renal cell carcinoma cells, thus promoting the release of cytochrome C enzymes and inducing apoptosis in A498 cells. Here, CYCS is linked to hereditary clear cell renal cell carcinoma.