There has also been a report of the activation of the catenin pathway contributing to promote immune evasion and PD-1 resistance in HCC, while the expression of chemokine (C-C motif) ligand 5 (CCL5) in MYC has shown potential in restoring immune recognition of HCC (Ruiz de Galarreta et al., 2019). This evidence concerns the gene CCL5 and hepatocellular carcinoma.