HMGB1 and neoplasm: By inducing immunogenic cell death (ICD) in tumor cells, radiotherapy can elicit an immune response accompanied by the release of specific signaling molecules assumed to be damage-associated molecular patterns (DAMPs), including high mobility group protein 1 (HMGB1), calreticulin (CRT), heat shock proteins (HSP70, HSP90), and adenosine-5′-triphosphate (ATP) (Rodriguez-Ruiz et al., 2019).