Finally, the risk score was calculated by the following formula (Figure 1C): tumor-associated endothelial signature score = 0.180855332*ADD1 + 0.059530341*ALOX12 + 0.145361104 *CXCL10 - 0.081730252*F2RL1 + 0.001225741*ITGAX − 0.004914148*MET. The gene discussed is MET; the disease is neoplasm.