EGFR and colorectal carcinoma: A phase II trial of cetuximab with irinotecan was conducted in patients with EGFR-positive colorectal cancer who were refractory to both 5-fluorouracil (5-FU) and Irinotecan because preclinical and early clinical research indicate that cetuximab might reverse irinotecan resistance in CRC both in vitro and in vivo.