Numerous studies have demonstrated that telomerase has a high-level telomere-specific reverse transcriptase (hTERT), which improves Nuclear factor erythroid 2-related factor 2 (NRF2) synthesis by recruiting Y-box binding protein 1 (YBX1) to trigger the NRF2 promoter, promoting CRC proliferation and migration. This evidence concerns the gene YBX1 and colorectal carcinoma.