CRC tumor cells may regulate tumor immune cell infiltration through lymph node metastasis-related characteristic genes (KIF1A, TMEM59L, CLCA1, COL9A3, GDF5, TUBB2B, STMN2, FOXN1, and SCN5A) to form lymph node metastasis. This evidence concerns the gene TMEM59L and colorectal carcinoma.