It was discovered through study that its expression is decreased in the tumor tissues and serum of CRC patients [33], the OS rate of patients with low CLCA1 expression was significantly lower than that of patients with high CLCA1 expression, and the recurrence rate in patients with low CLCA1 expression was higher than that of patients with high CLCA1 expression [34]. The gene discussed is CLCA1; the disease is neoplasm.