66 patients, serial venous blood samples at 3, 6, 12, 18, 24, 48, 72, 96, and 120 h after stroke onset.Increase of NSE as well as of tau was highly correlated with severity of neurological deficits, infarct volume and with the functional outcome at 3 months. NSE release was associated with the neurovascular status on admission. This evidence concerns the gene ENO2 and Stroke.