Interestingly, authors found that the PSCI group exhibited significantly higher levels of NF-L within 48 h of stroke onset; levels of NF-L were negatively correlated with cognitive impairment defined by Montreal Cognitive Assessment (MOCA) (MOCA <26) at 90 days after stroke onset, and directly correlated with age, cerebral infarction volumes and NIHSS score (76). The gene discussed is NEFL; the disease is Cognitive impairment.