This is also confirmed by a recent retrospective study on head trauma and remote injury, involving a total of 164 subjects, 94 PD patients and 70 healthy controls, in which the levels of CSF tau were found to be increased in a subgroup of PD patients who reported lifetime head trauma preceding diagnosis, probably due to extended degeneration or occurrence of tauopathy (121). The gene discussed is MAPT; the disease is tauopathy.