NPTX2 and Alzheimer disease: The prominent role of pentraxins (PTXs), including neuronal pentraxin-1 (NPTX-1), neuronal pentraxin-2 (NPTX-2), and C-reactive protein (CRP) in synaptic plasticity raises the possibility that its expression may be altered in AD that are characterized by synaptic dysfunction and loss [5].