MAPT and Alzheimer disease: Notably, pathways and molecules regulating axon guidance and synaptic function have also been broadly connected to AD and related traits (e.g., amyloid, tau, neurodegeneration) in the literature (Cissé et al., 2011; Jun et al., 2014, Wetzel-Smith et al., 2014; Jiang et al., 2015; Giri et al., 2016; Hashimoto et al., 2016; Kang et al., 2016; Zuko et al., 2016; Oguro-Ando et al., 2017; Han et al., 2018; Li et al., 2018; Liu et al., 2018; Lee et al., 2019; Whelan et al., 2019; Yang et al., 2019; Bamford et al., 2020; Cuestas Torres and Cardenas, 2020; Chen et al., 2021; Zhang et al., 2021).