Twelve individual axon guidance genes were dysregulated in all three cancers examined, namely, BOC, CXCL12, EDNRA, EFNA5, EPHA2, FLRT3, PLXNC1, RAC2, SEMA3C, TRIO, UNC5B, and WNT5A. By grouping ligand/receptor genes from the same pathway together, we noted that the individual gene paralog disrupted often differed between different datasets or different cancers. Here, RAC2 is linked to cancer.