Twelve individual axon guidance genes were dysregulated in all three cancers examined, namely, BOC, CXCL12, EDNRA, EFNA5, EPHA2, FLRT3, PLXNC1, RAC2, SEMA3C, TRIO, UNC5B, and WNT5A. By grouping ligand/receptor genes from the same pathway together, we noted that the individual gene paralog disrupted often differed between different datasets or different cancers. This evidence concerns the gene EFNA5 and cancer.