Strikingly, for PDAC, all ephrin genes examined showed a statistically significant worse survival when expressed above the cutoff levels, whereas for HNSCC and STAD, this was restricted to a few members of the family, EFNA1, EFNB1, and EFNB2 for HNSCC and EFNA5 for STAD (Figures 6, 7B; Supplementary Table 12). Here, EFNA1 is linked to head and neck squamous cell carcinoma.