GH1 and 3-M syndrome: Most early studies reported that rhGH was ineffective for patients with 3M syndrome, and did not recommend growth hormone treatment (Huber et al., 2011; Meazza et al., 2013; Wang et al., 2019; Khachnaoui-Zaafrane et al., 2022); however, there have been literature reports that many patients have been effectively treated with growth hormone in recent years.