COPD: chronic obstructive pulmonary disease; CABG: coronary artery bypass graft surgery; VR: valvular replacement; PRBC: packed red blood cells; INR: international normalized ratio; PT: prothrombin time; aPTT: activated partial thromboplastin time; HbA1c, hemoglobin A1C; LOS: length of stay. This evidence concerns the gene F2 and chronic obstructive pulmonary disease.