ADT: androgen deprivation therapy; DRE: digital rectal examination; HT: hormone therapy (mentioned separately from ADT as per QI); PC: prostate cancer; PSA: prostate-specific antigen; RT: radiotherapy; TRUS: transrectal ultrasound; TURP: transurethral prostatectomy; WHO: World Health Organization. Here, KLK3 is linked to pachyonychia congenita.