Compared with placebo, pioglitazone improved steatosis grade with RR = 1.78 (p = 0.03), inflammation grade with RR = 2.05 (p < 0.00001), ballooning grade with RR = 1.74 (p = 0.0007) but no significant change in fibrosis stage. Significantly reduced the plasma AST, and ALT and significantly increased HDL. This evidence concerns the gene GPT and steatosis.