While a component of oxidative stress is mediated by pro-oxidant signaling such as Ang II, norepinephrine, and cytokines (Patel and Zheng, 2012), there is a reduction of antioxidant enzymes production that contribute to excessive ROS in the central nervous system of animals with CHF and hypertension (Gao et al., 2007). This evidence concerns the gene AGT and hypertensive disorder.