For instance, COX‐2 expression is upregulated in a variety of tumor cells, and its downstream metabolite TXA2 binds to the G‐protein‐coupled receptors P2Y and TBXA2R on the surface of platelets, inducing platelet activation to bind to tumor cells and promoting their hematogenous metastasis.104. The gene discussed is TBXA2R; the disease is neoplasm.