A study making use of scRNA-seq datasets from scREAD to analyze the entorhinal cortex of AD brains found that phosphoinositide 3‐kinase (PI3K)/protein kinase B (AKT) signaling, Wnt signaling, neuroactive ligand-receptor interaction pathways, and neurodegeneration pathways were significantly impaired in astrocytes from the entorhinal cortex of AD patients [72]. The gene discussed is AKT1; the disease is Alzheimer disease.