Interestingly, the study revealed an overlap between central and peripheral transcriptomic signatures in PD that are characterized by anomalies in exocytosis and specific genes related to the SNARE complex including vesicle-associated membrane protein 2 (VAMP2), syntaxin 1A (STX1A), and p21-activated kinase 1 (PAK1) [61]. This evidence concerns the gene PAK1 and Parkinson disease.