CCL2 and Hepatic fibrosis: In the functional regulation analysis, we showed that genes with altered expression after TGT treatment were closely involved in the regulation of the activation, inflammation, and phagocytosis of LCM cells, mediated by various cytokines, including IL-6, CCL2, and CCL7. Our findings are in accordance with published papers, which confirmed the contributions of activated LCMs in the liver under inflammatory conditions by regulating liver injury as well as liver fibrosis [[51], [52]].