RELA and Alzheimer disease: This effect for anatabine has not been reported to date; only a few studies have described the anti-inflammatory effects of anatabine and its sister alkaloid anabasine in animal models of Alzheimer’s disease, with the effects mostly mediated by suppressing phosphorylation of STAT3 and p65 (also known as RELA) (Paris et al., 2013; Verma et al., 2015).