Moreover, among the top ten genes, FIBP was found to be overexpressed in a specific group of CLL patients affected by a large loss at the 13q14 locus (83); as previously noted also, IGF1R was identified as overexpressed in various CLL subsets, suggesting a contribution to CLL pathology (63, 81, 84, 85). Here, IGF1R is linked to B-cell chronic lymphocytic leukemia.