The effects of miR-342-5p were comparable on both these two cell lines (1.4-fold decrease in MG-63 cells and 1.7-fold in SaOS-2 cells).MiR-4270 significantly decreased Bcl-xL protein expression in all three osteosarcoma cell lines (by 2.5-fold in HOS cells, 5-fold in MG-63 cells, and 1.4-fold in SaOS-2 cells) (Figure 6). Here, BCL2L1 is linked to osteosarcoma.