The DisGeNET module showed the relationship of different signature genes with other human diseases like acute coronary syndrome (HSPA8, GSN, TUBA1C); transient ischemic attack (CYCS, C3); crescendo transient ischemic attack (CYCS, C3); paratuberculosis (C3, GSN); brain stem ischemia, transient (CYCS, C3); carotid circulation transient ischemic attack (CYCS, C3); posterior circulation transient ischemic attack (CYCS, C3), transient ischemic attack; vertebrobasilar circulation (CYCS, C3), transient ischemic attack; anterior circulation (CYCS, C3); and transient cerebral ischemia (CYCS, C3). This evidence concerns the gene HSPA8 and acute coronary syndrome.