We found that Blmh depletion downregulated Phf8 in mouse brain (Fig. 2A, Supplementary Figure 1A) and mouse neuroblastoma cells (Supplementary Figures 2B and 3B), upregulated AβPP in mouse brain (Fig. 2H, Supplementary Figure 1I) and mouse neuroblastoma cells (Supplementary Figures 2F and 3D), and Aβ in mouse brain (Fig. 6D-E, I-J) and mouse neuroblastoma cells (Fig. 5A, B). Here, APP is linked to neuroblastoma.