PHF8 and Alzheimer disease: Our present findings that Phf8 depletion in mouse neuroblastoma cells, induced by Phf8 gene silencing (Supplementary Figure 4A) or by supplementation with Hcy-thiolactone or N-Hcy-protein (Fig. 3A), significantly increased Aβ accumulation (Supplementary Figure 4J, K; Fig. 5C, D), suggest that Phf8 depletion can also underly the association of HHcy with AD [53].