To elucidate the mechanism by which Blmh depletion impacts Phf8 and its downstream effects on mTOR, autophagy, and AβPP, we first examined whether our findings in Blmh-/- mice can be recapitulated in cultured mouse neuroblastoma N2a-APPswe cells carrying a mutated human AβPP transgene. Here, PHF8 is linked to neuroblastoma.