Since dysregulated mTOR signaling and autophagy have been implicated in Aβ accumulation in AD brains [35–38], and H4K20me1 demethylation by PHF8 is important for maintaining homeostasis of mTOR signaling, we examined how these processes are affected in brains of Blmh-/-versus Blmh+/+ mice as well as transgenic Blmh-/-5xFAD versus Blmh+/+5xFAD mice. This evidence concerns the gene BLMH and Alzheimer disease.