Our findings that AβPP upregulation (Fig. 2H, Supplementary Figure 1I) was associated with Becn1 downregulation in brains of Blmh-/- (Fig. 2E) and Blmh-/-5xFAD mice (Supplementary Figure 1E) as well as in N2a-APPswe mouse neuroblastoma cells (Supplementary Figure 2F, G; Supplementary Figure 3D, G) suggest another pathway ((iii) in Fig. 7B) leading to Aβ accumulation. This evidence concerns the gene BECN1 and neuroblastoma.