Indeed, as we also found in the present study, treatments with Hcy-thiolactone or N-Hcy-protein induce changes in the Phf8->H4K20me1->mTOR->autophagy pathway and Aβ accumulation in mouse neuroblastoma cells (Figs. 3 and 5C, 5D) like those seen in Blmh-/- mice or mice fed with high Met diet (Fig. 2, Supplementary Figure 1, Fig. 6I, J). The gene discussed is BLMH; the disease is neuroblastoma.