BLMH and neuroblastoma: The findings that Phf8 expression was significantly reduced in the brains of Blmh-/- (Fig. 2A) and Blmh-/-5xFAD mice (Supplementary Figure 1A) and in the Blmh-silenced (Supplementary Figures 2B and 3B) or Hcy metabolite-treated (Fig. 3A) mouse neuroblastoma N2a-APPswe cells, suggested that Phf8 depletion by itself can affect biochemical pathways leading to Aβ accumulation.