Considering the lack of pharmacological inhibitors of TRPM7 and taking into account recent evidence that TRPM7 may be considered a putative target of miRNA135a,6 the aims of the present paper were to evaluate the effect of the miRNA135a in cerebral ischemia and to verify whether TRPM7 may be responsible for miR135a effects during ischemic conditions. Here, TRPM7 is linked to brain ischemia.