The present study targets the variants rs10069690, rs10228682, rs251796, and rs2975843 in genes – TERT, POT1, and TERF2, respectively, from the shelterin complex among 723 individuals (162 non-small cell lung cancer cases and 561 healthy control) in the ethnic population of Jammu and Kashmir, North India for NSCLC risk. This evidence concerns the gene TERF2 and non-small cell lung carcinoma.