The present study targeted the genetic variations in telomere maintenance genes like TERT, POT1, and TERF2 in the ethnic population of Jammu and Kashmir, North India, for NSCLC risk using MassARRAY.With this perspective, the association between genetic variant rs10069690 of TERT (Telomere Reverse Transcriptase), rs10228682 of POT1 (Protection of Telomeres), rs251796, rs2975843 of TERF2 (Telomere Repeating Factor 2) and non-small cell lung cancer was evaluated. Here, TERF2 is linked to non-small cell lung carcinoma.