Disease progression and acquired immunodeficiency in CD4 T-cell function may however lead to an increase in the replicative rate of the virus and infection in the adrenal glands or pituitary gland, as occurs in AIDS by decreasing surveillance of herpesviruses (such as cytomegalovirus), allowing them to infect and deplete cortisol stores [236, 266]. Here, CD4 is linked to acquired immunodeficiency.