Increased overexpression of MTs in cases of serum zinc deficiency causes hypoplasia of primary and secondary lymphoid organs (thymus, spleen, lymph nodes, and Payer’s plaques), decreased secretion of Zn-thymulin in the thymus, a decrease in the number of total T lymphocytes, altered T-helper activation and function, reduced cytotoxic activity of NK cells, Th1/Th2 imbalance with increased release of Th2 cytokines, and polarization of Treg versus Th17 cells, ultimately leading to a state of immunosuppression with low resistance to infections [236, 329, 335]. This evidence concerns the gene TIMM8A and Zinc deficiency.