Another factor influencing microclot formation is endothelial damage caused by EBV infection, either by positive upregulation of NOX2 by EBNA-1 in EBV-transformed endothelial cells or by activation of TLR3 by EBERs, where NOX2 activation causes vasoconstriction and thrombosis through platelet aggregation by increased overproduction of hydrogen peroxide, isoprostane, or inactivation of nitric oxide [256, 302, 316, 317]. The gene discussed is CYBB; the disease is Epstein-Barr virus infection.