Both IL-10 and TGF-β1 (anti-inflammatory and immunosuppressive cytokines) are elevated in EBV infections, where they are secreted by EBV latency cells and regulatory T cells to counteract proinflammatory cytokines and to evade CD4 T cells [8, 264, 265]. The gene discussed is CD4; the disease is Epstein-Barr virus infection.