In brain areas of increased Cu use, ceruloplasmin deficiency and activation of microglia in response to the presence of viral genetic material could also contribute to the overstimulation of NMDA receptors, increased levels of nitric oxide/peroxynitrite levels, and the cognitive impairment present in ME/CFS patients [346, 369, 370]. This evidence concerns the gene CP and myalgic encephalomeyelitis/chronic fatigue syndrome.