IFNG and infection: Therefore, depending on the tissue infiltrated by the B cells with EBV latency in an individual with EBV “weak” HLA-II alleles, the formation of EBV-infected ectopic lymphoid structures and an infection of other cell types by the increased expression of HLA-II as a result of increased IFN-γ, one type or another of EBV-associated disease may develop [171–176, 195].