These infected tissues, when not controlled by the adaptive response, could end up with chronic inflammation due to the activation of TLR3 receptors or RIG-I, which results in continuous detection of viral genetic material (EBERs) [231–233], causing a chronic innate response and inflammation through the continuous release of proinflammatory cytokines, generating an increase in IL-1, IL-6, TNFα and IFN-γ in individuals with ME/CFS [37]. Here, TNF is linked to myalgic encephalomeyelitis/chronic fatigue syndrome.