AGT and Hypertension: Macrophages are considered as key players in modulating the inflammatory status in hypertension, and studies have reported that perivascular inflammation in hypertension is triggered by infiltrated macrophages.25,45,46 Moreover, depleting macrophages in mice attenuated hypertension, endothelial dysfunction, and vascular oxidative stress in response to AngII stimulation,47 which strengthened evidence of the important role of macrophages.