Clinical studies have revealed that there are change in iron metabolism in substance use disorders including alcohol abuser.28–31,52,53 A study conducted in chronic cocaine user revealed that iron content was significantly higher in basal ganglia reward regions than that of control individuals.54 It was also reported that iron mediates morphine -induced ferritin heavy chain upregulation.55Mice with mitochondrial coq7 mutant had decreased iron content in striatum and hippocampus that is associated with attenuation development of METH- induced CPP. Here, FTH1 is linked to alcohol abuse.