Moreover, our previous study found that mitochondrial coq7 (mClk1) deficiency-induced upregulation of HIF-1α which resulted in cellular iron deficiency and DAT membrane accumulation, ultimately, lead to attenuation of METH-induced conditioned place preference (CPP),32 which further implicating a critical role for HIF-1α-mediated iron metabolism in the development of drug reward. This evidence concerns the gene SLC6A3 and Iron deficiency anemia.