According to the ROC curve analysis, the area under the curve (AUC) values of PD with anxiety and EDS based on plasma SIRT1 levels were 0.685 and 0.694, the sensitivity values were 65.6% and 90%, the specificity values were 68.7% and 44.7%, and the cutoff values were 39.20 and 49.13, respectively (Fig. 2a, b, c, d). This evidence concerns the gene SIRT1 and Parkinson disease.