Plasma SIRT1 levels in the anxiety subgroup and the EDS subgroup were lower than those in the non-anxiety subgroup and the without EDS subgroup, while plasma SIRT1 levels in the cognitive impairment subgroup were significantly lower than those in the non-cognitive impairment subgroup (35.71 (33.04, 49.58) vs. 38.57(33.26, 56.13), P = 0.289; 36.29 (32.83, 50.72) vs. 49.14 (36.23, 94.24), P = 0.023; 35.54 (29.91, 40.17) vs. 43.32(34.37, 65.25), P = 0.004; 34.21 (29.91, 46.30) vs. 42.62(35.81, 68.82), P = 0.001). This evidence concerns the gene SIRT1 and Cognitive impairment.