Previous studies have shown that patients with PD with EDS showed extensive cortical and subcortical changes, such as frontal lobe atrophy, combined cortical hypoperfusion, and decreased dopamine uptake by the dopamine transporter (DAT) in the caudate nucleus, and abnormal neural activity in patients with PD with EDS and PD without EDS, the abnormality of low frequency fluctuation amplitude (ALFF) at the local level in the pons and frontal lobe, the decrease of ALFF in cingulate cortex, and the reduction of functional connection at cingulate cortex and precuneus network level [26]. This evidence concerns the gene SLC6A3 and Ehlers-Danlos syndrome.