A clinical study showed that it is discrepancy for serum ceruloplasmin (CP) levels in PD patients, and that serum CP reduction is more easily to accelerate the progression of PD than that of serum CP normal patients 36, which might be the same as the global Cp gene deficiency related parkinsonism symptoms in aceruloplasminemia patients and Cp-/- mice 37,38. This evidence concerns the gene CP and Parkinsonism.