ERBB2 and gastric cancer: One of the cytotoxic warheads, MMAE, as a dolastatin-10 peptide derivative, with potent antimitotic activity that inhibites cell division by blocking the tubulin polymerization, which is the most commonly-used warhead in clinically-approved ADCs and facilitates potent efficacy against other gastrointestinal cancer (gastric cancer) in RC48, a HER2-targeted ADC34.