To evaluate the role of clusterin in psoriasis, IMQ was applied to the shaved skin of clusterin-knockout (clusterin−/−) and WT mice for 3 days (n = 6 per group), while the control group was treated with Vaseline (VAS) (n = 2 per group) for the same 3 days (Fig. 1A). This evidence concerns the gene CLU and psoriasis.