To evaluate the effect of clusterin on IMQ-induced psoriasis-like inflammatory reactions in IL-10−/− mice, we treated IL-10−/− and IL-10/clusterin double knockout (DKO) mice with topical IMQ or VAS on Days 1, 3, 5, and 8 (n = 5 per group) and sacrificed the mice on day 10 (Fig. 2A). The gene discussed is IL10; the disease is psoriasis.