In Supplementary Table S2, the enriched RELA-PTGS2/NOS2 axis contributes to angiogenesis in KEGG small cell lung cancer pathway85 (see Supplementary Fig. S1), implying that Methazolamide may inhibit the progression of AS by down-regulating the angiogenesis process86. This evidence concerns the gene PTGS2 and small cell lung carcinoma.