The findings that Tph1−/− mice are also susceptible to gastrointestinal51 and vaginal (Fig. S8) candidiasis, while further pointing to the sensitivity of fungi to local changes of 5-HT, lead to a conceptualization that among the multitasking activity of 5-HT is an integrated physiological and behavioral response to inflammatory events and pathogens at the host-pathogen interface. This evidence concerns the gene TPH1 and candidiasis.