RBP3 and alopecia universalis congenita: Moreover, pre-clinical animal studies showed that the adoptive transfer of activated interphotoreceptor retinoid-binding protein (IRBP)-specific Th17 cells into naïve mice could induce EAU, while suppression of antigen-specific Th17 cell responses could alleviate EAU [11, 12], suggesting the importance of controlling pathogenic Th17 cells and its regulatory pathways in AU treatment.