HNRNPA2B1 and obesity due to melanocortin 4 receptor deficiency: hnRNPA2B1 plays a vital role in a variety of diseases including amyotrophic lateral sclerosis [36, 37], pulmonary arterial hypertension [38], obesity [39] and innate immune response [40], particularly in cancer, where hnRNPA2B1 has been recommended as a candidate marker for cancer screening [7].