In summary, our paper elucidated that upregulation of CRNDE enhanced hnRNPA2B1 protein stability via inhibiting TRIM21-mediated K63 ubiquitin-dependent degradation, and then promoted nuclear export and translation of KRAS mRNA, which subsequently activated MAPK oncogenic signaling in CRC cells. The gene discussed is HNRNPA2B1; the disease is colorectal carcinoma.