According to our TMA data, higher hnRNPA2B1 expression was confirmed to be strongly correlated with more malignant pathological grade (Fig. 1A, P = 0.0099), deeper tumor invasion (Fig. S1G, P = 0.0440), more severe lymph node metastasis (Fig. S1H, P < 0.0001), more advanced TNM stage (Fig. 1B, P < 0.0001) (Table 1), and worse survival burden of CRC (Fig. 1C, P = 0.0403). This evidence concerns the gene HNRNPA2B1 and neoplasm.