The NLRP3 inflammasome, which is an intracellular multimeric protein signaling complex, can activate potent inflammatory responses and has been associated with many inflammatory and autoimmune diseases, including diabetes, atherosclerosis, asthma, systemic lupus erythematosus and rheumatoid arthritis [22, 23, 45]. This evidence concerns the gene NLRP3 and rheumatoid arthritis.