The NLRP3 inflammasome, which is an intracellular multimeric protein signaling complex, can activate potent inflammatory responses and has been associated with many inflammatory and autoimmune diseases, including diabetes, atherosclerosis, asthma, systemic lupus erythematosus and rheumatoid arthritis [22, 23, 45]. The gene discussed is NLRP3; the disease is diabetes mellitus.