In addition to the HPV(+) and HPV(−) oropharyngeal squamous cell carcinomas, we also tested OIS-PRM on FFPE tumor punches from a cohort of 19 HPV(−) oral squamous cell carcinomas that were genotyped for NRF2 (Fig. 7A). Here, NFE2L2 is linked to oral cavity squamous cell carcinoma.