The cytokines CCL2 and CXCL1 were found here to be upregulated in the BA9 region of AD brain in agreement with previous reports (Barroeta-Espar et al., 2019, Perez-Nievas et al., 2021, Sokolova et al., 2009) suggesting a potential involvement of P2X7R in the increased presence of these cytokines in AD. Here, CCL2 is linked to Alzheimer disease.