P2RX7 mRNA and protein are upregulated in end-stage post-mortem AD brain, although no correlation between histopathological (Braak) disease stage and receptor expression was ever analysed (di Lauro et al., 2022, Martinez-Frailes et al., 2019, Martin et al., 2019, McLarnon et al., 2006); likewise P2X7Rs are upregulated in mouse models of amyloidosis (Lee et al., 2011, Ryu and McLarnon, 2008) and tauopathies (Carvalho et al., 2021). The gene discussed is P2RX7; the disease is Alzheimer disease.