APP and frontotemporal dementia: Pharmacological antagonism of P2X7R ameliorates cognitive deficits in amyloid precursor protein (APP) transgenic mice and in mice injected with human Aβ (Chen et al., 2014, Martin et al., 2019), as well as in tauopathy mouse models expressing FTD-causing tau mutations (Carvalho et al., 2021, di Lauro et al., 2022).