IL18 and Alzheimer disease: Our data further supports that microglial P2X7R could contribute to elevations in IL-1β and IL-18, end-products of the NLRP3 inflammasome pathway, in AD brain and peripheral fluids (Brosseron et al., 2014, Ising et al., 2019, Griffin et al., 1989, Ojala et al., 2009).