MAPT and frontotemporal dementia: For this purpose, organotypic mouse brain slice cultures (BSCs) were transduced with viral vectors to drive the expression of EGFP-tagged WT 0N4R human tau or mutant 0N4R human tau carrying the FTD-causing MAPT mutations P301L and S320F which show increased propensity to aggregate in vitro (Rosso et al., 2002, Strang et al., 2018) and ex vivo (Croft et al., 2019).