Similarly, P2X7R-mediated release of IL-1β by microglia is described in a mouse model of tauopathy (Di Lauro et al., 2022) with IL-1β believed to influence tau phosphorylation through actions on GSK-3 (di Lauro et al., 2022, Ghosh et al., 2013), although others suggest the involvement of different mechanisms (Carvalho et al., 2021, Ruan et al., 2020). This evidence concerns the gene IL1B and tauopathy.