MAPT and tauopathy: Similarly, P2X7R-mediated release of IL-1β by microglia is described in a mouse model of tauopathy (Di Lauro et al., 2022) with IL-1β believed to influence tau phosphorylation through actions on GSK-3 (di Lauro et al., 2022, Ghosh et al., 2013), although others suggest the involvement of different mechanisms (Carvalho et al., 2021, Ruan et al., 2020).