In mouse models, CCL2 activity is linked with Aβ and tau deposition, and cognitive decline (el Khoury et al., 2007, Gutierrez et al., 2019, Joly-Amado et al., 2020, Kiyota et al., 2013, Yamamoto et al., 2005), and interactions between astrocytic CXCL1 and its receptor CXCR2 mediate Aβ- induced tau modifications and synapse toxicity in vitro (Perez-Nievas et al., 2021, Xia and Hyman, 2002). The gene discussed is CXCL1; the disease is Mental deterioration.