Our data further supports that microglial P2X7R could contribute to elevations in IL-1β and IL-18, end-products of the NLRP3 inflammasome pathway, in AD brain and peripheral fluids (Brosseron et al., 2014, Ising et al., 2019, Griffin et al., 1989, Ojala et al., 2009). Here, NLRP3 is linked to Alzheimer disease.