P2RX7 and Alzheimer disease: An important future goal is to uncover the association between P2X7R and functional glial subtypes in AD by quantitatively examining the expression of P2RX7 in disease-associated subpopulations of astrocytes (Habib et al., 2020), microglia (Mathys et al., 2019) or oligodendrocytes (Sadick et al., 2022), where P2RX7 might also be expressed (Pietrowski et al., 2021, Lau et al., 2020).