Notably, RNA-seq data from CRND8 transgenic mice over-expressing human APP (K670N/M671L and V717F mutations) (Chishti et al., 2001, McFarland et al., 2021) showed an age-dependant increase in P2rx7 mRNA (Fig. 2e,Table S4), coinciding with progressive amyloidopathy, which further supports an association between P2X7R and senile plaques in AD, in agreement with previous reports (Martin et al., 2019, Martinez-Frailes et al., 2019). This evidence concerns the gene APP and Alzheimer disease.