MAPT and tauopathy: This upregulation together with evidence that P2X7R modulates signalling cascades in astrocytes and microglia that are implicated in pathological changes in tau (Joly-Amado et al., 2020, Kitazawa et al., 2011, Mann et al., 2022, Perez-Nievas et al., 2021) prompted us to examine the effects of P2X7R antagonism in a disease-relevant model of tauopathy.