NLRP3 and Cognitive impairment: Nevertheless, these data implicate P2X7R upstream of microglial NLRP3 inflammasome-driven progression of Aβ and tau pathology and accompanying cognitive deficits in mice (Heneka et al., 2013, Ising et al., 2019, Stancu et al., 2019, Venegas et al., 2017).