Although it is not straightforward to link this observation to our functional findings ex vivo, it should be noted that recent studies in AD brain have highlighted the heterogeneity and diversity of tau pathology across individuals (Dujardin et al., 2018) which is associated with complex patterns of post-translational modifications altering tau aggregation and propagation (Wesseling et al., 2020). Here, MAPT is linked to Alzheimer disease.