Similar results are observed regarding significant higher odds to have either-cognitive-frailty-or-depression and to have both-cognitive-frailty-and-depression with increasing GDF15 quartiles in unadjusted (Fig. 2A and B, crude model, all adults) and in age, BMI, sex, comorbidities and hsCRP-adjusted (Fig. 2A and B, model 1, all adults) logistic regression analyses. This evidence concerns the gene GDF15 and depressive disorder.