GFAP and glioblastoma: In terms of biomedicalapplications, there is an urgent need todevelop low-cost sensitive tests for the detection of brain tumorsto help general practitioners in primary care.51 The most common malignant primary brain tumor called glioblastoma(GBM) is characterized by abnormal blood vessels resulting in a leakyBlood–Brain Barrier.52,53 Glial Fibrillary AcidProtein (GFAP) is unique to the brain and not present in normal peripheralblood.